ABSTRACT
BCL2 family is a large family of apoptosis regulating proteins consisting of both blockers and promoters of cell death. Immunological processes and a variety of cytokines may play a role in pathophysiological process. Defective regulation of programmed cell death [apoptosis] also play a role in development of Behcet's disease. To investigate the level of BCL2 and IL13in BD and to determine their to relation monitory disease activity. This study was conducted on thirty patients [15 active and 15 inactive] and 15-health control, the activity of BD was evaluated according to international study group for BD disease, using ELISA technique for IL13 and flow cytometry for BCL2. Elevated serum levels of IL13 in patient with active BD than inactive and both had elevated levels than control[P< 0.01] and also the serum levels of Bcl2 was elevated in patient with active BD than inactive and control[P< 0.01]. The data suggested that IL13 and BCL2 could be involved in the pathogenesis of BD and its serum levels can be used as marker to monitor disease activity